Novel Insertion/Deletion Polymorphisms and Genetic Studies of the Shadow of Prion Protein (SPRN) in Raccoon Dogs
Abstract
Simple Summary Prion diseases are rare and fatal neurodegenerative disorders associated with the shadow of the prion protein (SPRN) gene. Raccoon dogs, members of the Canidae family, may exhibit resistance to these diseases, yet the specific factors underlying this resistance remain unidentified. In this study, we amplified and analyzed the SPRN gene in raccoon dogs using PCR and DNA sequencing, identifying five novel genetic polymorphisms. In silico analysis assessed the pathogenic potential of these insertion/deletion polymorphisms, indicating that they are non-pathogenic. This research marks the first exploration of the genetic and structural characteristics of the SPRN gene in raccoon dogs.
Read the paper
Related studies
- Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
- Challenges in Chagas Disease Drug Development
- T Cell Specificity: A Great Challenge in Chagas Disease
- Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
- Rapid Molecular Detection of Terbinafine-resistant Dermatophytes
- Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.