Efficacy of Prophylactic Magnesium Therapy for the Prevention of Cisplatin-Induced Renal Injury: A Meta-Analysis
Abstract
Background/Objectives: Cisplatin is used as treatment for various malignant tumors; nevertheless, this anticancer drug frequently causes side effects such as renal damage and hypomagnesemia. Hypomagnesemia has been suggested to cause renal damage, and preventing hypomagnesemia through magnesium supplementation is necessary to continue treatment while maintaining treatment intensity. Although the usefulness of magnesium supplementation has been previously evaluated, problems with the amount of magnesium supplementation and sample size have been identified. This study aimed to examine the usefulness and amount of magnesium supplementation by conducting a meta-analysis of a large number of studies. Methods: This meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. Relevant studies published in PubMed, Scopus, Ichushi, and Cochrane Library databases from inception to 31 December 2025 were selected. The searched text combinations were “cisplatin” and “magnesium.” Results: Magnesium supplementation showed an inhibitory effect on cisplatin-induced renal injury. The inhibitory effect of magnesium supplementation showed no difference among the three dose groups (<10 mEq, 10–<20 mEq, and ≥20 mEq). Conclusions: Magnesium supplementation is useful for preventing cisplatin-induced nephrotoxicity, irrespective of its dose. The results of this meta-analysis may be clinically helpful in preventing hypomagnesemia-induced…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
- A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
- Bioaccessibility and bioavailability of phenolic compounds
- The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
- Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery
- Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.