Role of Magnesium in Prophylaxis of Migraine
Abstract
Background: Circumstantial evidence points to be possible role of magnesium (Mg +2 ) deficiency in the pathogenesis of migraine and has raised questions about the clinical utility of magnesium as a therapeutic regimen in migraine.This was a prospective, randomized, double blind, placebo controlled trial comparing the efficacy and tolerability of 400mg magnesium hydroxide once daily (23 patients), 10 mg Propranolol 3 times daily (22 patients), 200 mg Navalproate twice daily (20 patients), and placebo (22 patients) in the prophylaxis of migraine diagnosed according to the criteria of the International Headache Society.Patients were evaluated for attack frequency, severity, drug side effects monthly for 3 months.Magnesium, Propranolol and Na-valproate were all superior to placebo (p0.05; which is not significant).Our result shows that magnesium significantly reduced the frequency of migraine attack and severity with no serious side effects compares well to established drugs like Propranolol and Na-valproate.Conclusion: The study was conducted to find out the role of magnesium in migraine prophylaxis.The present study found that magnesium significantly lowers the frequency of attack & severity of migraine.So magnesium can be used as an alternative agent for migraine prophylaxis for its effectiveness, well tolerability and less side effects.
How strong is the evidence?
Evidence Hub reads this as a randomized trial. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 23 participants or records.
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