A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome
Abstract
Vitamin E supplementation might have favorable effects on risk factors of polycystic ovary syndrome (PCOS). This systematic review and meta-analysis aimed to summarize the effects of vitamin E supplementation or vitamin E in combination with omega-3 or magnesium on PCOS. PubMed, Scopus, ISI Web of Science, Cochrane, Embase electronic databases, and Google scholar were searched for all available articles up to September 2022. Randomized controlled trials (RCTs) that examined the effect of vitamin E supplementation or vitamin E in combination with omega-3 or magnesium on lipid and glycemic profiles, anthropometric measurements, biomarkers of inflammation and oxidative stress, hormonal profile, and hirsutism score in patients with PCOS were included. Ten RCTs (with 504 participants) fulfilled the eligible criteria. Vitamin E supplementation or vitamin E in combination with omega-3 or magnesium in comparison to placebo could significantly reduce serum levels of TG (weighted mean difference: − 18.27 mg/dL, 95% CI − 34.68 to − 1.87), VLDL (− 5.88 mg/dL, 95% CI − 8.08 to − 3.68), LDL-c (− 12.84 mg/dL, 95% CI − 22.15 to − 3.52), TC (− 16.30 mg/dL, 95% CI − 29.74 to − 2.86), TC/HDL-c ratio (− 0.52, 95% CI − 0.87 to − 0.18), hs-CRP (− 0.60 ng/mL, 95% CI − 0.77 to − 0.44), hirsutism score (− 0.33, 95% CI − 0.65 to − 0.02) and significantly increase nitric oxide levels (2.79 µmol/L, 95% CI 0.79–4.79). No significant effect was found on HDL-c, glycemic indices, hormonal profile,…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 504 participants or records.
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