Magnesium Sulfate and Acute Migraine: A Randomized Clinical Trial
Abstract
DOI: 10.4328/ACAM.20072 Received: 2019-11-07 Accepted: 2020-01-05 Published Online: 2020-01-08 Printed: 2020-09-01 Ann Clin Anal Med 2020;11(5):369-373 Corresponding Author: Javad Mozafari, Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: [email protected] T: +98-612439152 Corresponding Author ORCID ID: https://orcid.org/0000-0002-8903-7138 Abstract Aim: In the current study we have aimed to evaluate the magnesium sulfate, as an adjuvant treatment, in managing acute migraine. Further knowledge of the migraine pathology elucidates the role of magnesium in the treatment of the disease. Materials and Methods: Patients with migraine referred to Ahvaz Golestan Hospital emergency department were included in this randomized clinical trial. Patients’ characteristics including gender, age, and weight were extracted from the files. Patients were randomly divided into two equal groups using block randomization method. Group A received 2 g intravenous infusion (I.V) of Magnesium sulfate along with 10 mg metoclopramide. And group B received 10 mg metoclopramide and placebo. The pain level was measured by NRS at baseline, 15, 30, and 45 minutes after intervention. Results: Eighty patients were randomly assigned into two groups, forty (50%) were male. Most patients were between 30 and 40 years old. The baseline characteristics have not shown significant differences between the groups. The mean pain level at admission was not…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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