Association Between Intravenous Magnesium Sulfate and All-Cause Mortality in Patients With Acute Heart Failure: A Propensity Score-Matched Cohort Study in MIMIC-IV
Abstract
Background: Magnesium deficiency represents a prevalent electrolyte imbalance that notably heightens the risk of adverse cardiovascular incidents among individuals with heart failure. Research indicates that magnesium supplementation can diminish the frequency of negative events linked to hypomagnesemia in heart failure patients, while also enhancing the outcomes for critically ill individuals. Nevertheless, there remains a scarcity of studies investigating the effects of intravenous magnesium supplementation on mortality risk in those suffering from acute heart failure. This study aimed to explore the relationship between the administration of intravenous magnesium sulfate and the overall mortality risk in patients with acute heart failure who are admitted to intensive care units. Methods: This retrospective cohort study employed the Medical Information Mart for Intensive Care IV (MIMIC-IV) database (version 3.1), which encompasses the baseline clinical data of 10,031 patients diagnosed with acute heart failure. Propensity score matching and multivariate Cox regression analysis were utilized to assess the effects of intravenous magnesium sulfate on 28-day all-cause mortality. The evaluation of unmeasured confounding variables was undertaken through E-value calculations, while subgroup analyses were performed to ascertain the robustness of the results. Results: A total of 10,031 patients participated in the study, with 6240 belonging to the propensity-score matched group,…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 10,031 participants or records.
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