Specifics of migraine prevention in women of reproductive age
Abstract
Migraine is one of the most significant medical problems of our time, being the leading cause of disability and impaired quality of life in women of reproductive age. Rimegepant is an orally administered CGRP receptor antagonist with a unique dual-use concept, enabling both effective relief of acute attacks and long-term migraine prevention. To assess the efficacy, tolerability, and safety of rimegepant in women, a narrative literature review was conducted, including a systematic search of PubMed, Web of Science, Scopus, and eLIBRARY.RU. In the first stage, 412 publications were identified using titles and keywords. After an in-depth analysis of full-text versions, 138 studies were selected, containing data from randomized controlled trials, pharmacokinetic, longitudinal, and cohort studies, as well as systematic reviews and meta-analyses. Ninety-two articles were selected for qualitative analysis, and 27 articles were selected for a quantitative comparison of efficacy and safety indicators. The Introduction section utilized nine publications to substantiate the epidemiological and pathophysiological significance of the problem. Eighty-eight studies were excluded from the analysis due to failure to meet the inclusion criteria: lack of original data, duplicate samples, conference abstracts without full text, and studies outside the target population of women of reproductive age. The final review included 50 publications. The search period ranged from 2010 to 2016, with…
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