Status of Serum Calcium, Phosphorus, Magnesium and Copper in Hypothyroid Patients- A Case Control Study
Abstract
Introduction: Thyroid disorders are the most common endocrine abnormality in the world secondary to diabetes mellitus. Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. It influences the metabolism of all substrates including minerals. Many studies have shown that mineral metabolism is frequently disturbed in thyroid disorders. Aim: To estimate the levels of serum calcium, phosphorus, magnesium and copper in hypothyroid cases and to correlate each of the parameter with serum Triiodothyronine (T3), Thyroxine (T4), Free T3 (FT3), Free T4 (FT4) and Thyroid-Stimulating Hormone (TSH), respectively. Materials and Methods: The study was conducted on sixty newly confirmed hypothyroid cases based on the thyroid profile and sixty euthyroid cases were recruited as controls. Blood samples were collected from all the patients for the estimation of serum T3, T4, FT3, FT4, TSH, calcium, phosphorus and magnesium by autoanalyser method. Modified spectrophotometric micro-method was used to measure Serum copper using Bathocuprine Disulphonate Disodium Salt (BCDS) and Guanidine hydrochloride salt. The Statistical software namely SPSS 18.0, and R environment ver.3.2.2 were used for the analysis of the data. Results: Study results shows that mean serum calcium, magnesium and copper levels were significantly (p<0.001) decreased while serum phosphorus levels were increased significantly (p<0.001) in hypothyroid cases as compared to…
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