Cannabidiol for migraine prevention: a review of 52 cases
Abstract
The use of cannabidiol in migraine has become a topic of great interest for researchers, physicians, and patients seeking effective alternatives to alleviate this painful and debilitating condition. Among the various therapeutic applications of cannabis extract, the use of cannabidiol (CBD), one of its main components, has shown significant results in migraine treatment. Recent scientific studies indicate that CBD may reduce the frequency of migraine attacks and improve patients’ quality of life. A total of 52 patients diagnosed with migraine according to the International Classification of Headache Disorders criteria were studied between November 2021 and December 2024. These patients used full-spectrum cannabidiol oil during this period. A dose of 20 mg/day of cannabidiol was prescribed for 4 weeks, followed by an increase to 40 mg/day for the subsequent 8 weeks. Neurological reassessments were conducted at the 4th, 8th, and 12th weeks of treatment, measuring the frequency and intensity of attacks as well as functional disability using the MIDAS scale. After 4 weeks, 27 patients (51%) experienced a greater than 50% reduction in migraine frequency, and 14 patients (32.7%) had a greater than 50% reduction in migraine intensity. After 8 weeks, 36 patients (69.3%) showed a greater than 50% reduction in frequency, and 30 patients (57.7%) had a greater than 50% reduction in intensity. After 12 weeks, based on the MIDAS score evaluation, only 13.5% of patients showed no…
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