Flowable Dehydrated Amniotic Membrane Allograft Augments McDonald Cerclage in High-Risk Women for Preterm Birth Prevention, a Case Series
Abstract
The inability of the uterine cervix to retain a pregnancy in the second trimester is referred to as cervical insufficiency. The most common intervention for such cervical insufficiency to prevent preterm birth is a McDonald cerclage. However, the rate of success ranges from 4090%. This 3 patient case series is the first report of supplemental use of a dehydrated amniotic membrane allograft (DAMA; BioDRestore) at the cerclage suture sites as a means to improve success, measured by prevention of pre-term birth, reduction in complications of neonatal prematurity, and decreased length of hospitalization for mother and neonates.
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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