A personalized approach to the treatment and prevention of diabetic foot: molecular mechanisms and the role of taxifolin
Abstract
Aim. To substantiate the pathogenetic rationale for including aqueous solution of dihydroquercetin (taxifolin) in the comprehensive treatment of diabetic foot and to present the results of a case series on the application of this form in patients with trophic ulcers receiving standard treatment, as well as to compare the obtained results with current data on the molecular mechanisms of taxifolin action. Methods. A prospective observational study (case series, n=15) in patients with severe diabetic foot receiving standard therapy supplemented with aqueous dihydroquercetin per os and topically as a gel. The dynamics of ulcer healing (area, depth, granulation), laboratory markers of inflammation and oxidative stress (including malondialdehyde levels), and quality of life according to the SF-36 questionnaire were evaluated. Additionally, to compare the clinical results obtained with global practice, a targeted analysis of publications in PubMed, Scopus, and eLIBRARY databases for 2019–2024 was conducted on the pathogenesis of diabetic foot and the use of taxifolin/dihydroquercetin. Results. Complete ulcer healing within 6–10 weeks was achieved in 13 out of 15 patients (86.7%), while 2 patients (13.3%) showed a significant reduction in ulcer area (~75%) without complete closure by the end of the observation period. The mean reduction in ulcer area was 68 ± 18%, accompanied by decreased levels of C-reactive protein, malondialdehyde, leptin, and insulin, as well as improved quality…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 15 participants or records.
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