Folinic Acid Supplementation During Pregnancy in Two Women with Folate Receptor Alpha Autoantibodies: Potential Prevention of Autism Spectrum Disorder in Offspring
Abstract
This report presents two cases of pregnant women positive for folate receptor alpha (FRα) autoantibodies who received folinic acid supplementation. Both had previously given birth to children diagnosed with autism spectrum disorder (ASD). In subsequent pregnancies, folinic acid was administered preconceptionally and continually throughout gestation. The resulting offspring, monitored up to three years of age, exhibited typical neurodevelopment with no signs of ASD. These cases suggest that folinic acid supplementation during pregnancy may mitigate the risk of ASD in children born to mothers with FRα autoantibodies.
Read the paper
Related studies
- Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
- A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
- Bioaccessibility and bioavailability of phenolic compounds
- The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
- Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery
- Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.