P-107 incidental renal presentation of papillary thyroid carcinoma: a rare case report
Abstract
Abstract Introduction Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, usually presenting as a thyroid nodule or cervical lymphadenopathy. Distant metastases at diagnosis are rare, and initial presentation with an extrathyroidal lesion is extremely uncommon. Here, we report a case of PTC that initially presented as a renal mass resected for presumed renal malignancy, with subsequent confirmation of multifocal thyroid carcinoma and nodal metastases. Clinical Case A 44-year-old woman underwent partial nephrectomy for a suspicious left renal mass detected during screening. Histopathological analysis revealed metastatic papillary thyroid carcinoma (PTC). Microscopy showed colloid-containing tissue with focal calcifications, nuclear grooves, and intranuclear pseudoinclusions, consistent with PTC. Immunohistochemistry confirmed thyroid origin with positive staining for TTF-1, thyroglobulin, and PAX8, while PAX2 staining was negative. Subsequent total thyroidectomy with central lymph node dissection demonstrated multifocal PTC involving both lobes (1.2 cm in the right lobe and 1.2 cm in the left lobe), composed of classical and follicular variants. Lymphovascular invasion was present. Of eight lymph nodes dissected, six contained metastatic carcinoma, with the largest measuring 1 cm, without evidence of extracapsular spread. Psammoma bodies and calcifications were observed, necrosis was absent, and the closest tumor margin was 0.1 cm. Postoperatively, the…
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