Major outcomes in heart failure and cardiovascular diseases of the use of vitamin D, ubiquinone, and magnesium in nutrological cardiology: a systematic review
Abstract
Introduction: Heart failure (HF) and cardiovascular diseases (CVD) are the main causes of death in the population. According to data from the World Health Organization for 2023, of the 21.5 million deaths from these diseases. The beneficial metabolic effects of magnesium, vitamin D, and ubiquinone (coenzyme Q10) can be highlighted. Objective: It was to scientifically analyze the influence of the three elements Magnesium, Vitamin D, and ubiquinone (Coenzyme Q10) concerning heart failure, cardiovascular diseases and metabolic syndrome. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from June to July 2024 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 154 articles were found, and 80 articles were evaluated and 78 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 26 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =96.8% >50%. It was concluded that magnesium plays a fundamental role in glucose metabolism, insulin, and glycemic homeostasis, in the synthesis of adenosine triphosphate, proteins, and nucleic acids. However, further studies are needed to better clarify the role of…
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Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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