Synergistic Effects of Multiple Bioactive Ingredients in the Treatment of ADHD in Children: A Pathophysiological and Clinical Systematic Review
Abstract
Background and Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a complex neurodevelopmental disorder that affects the ability to pay attention, control hyperactivity, and regulate impulses. The utilization of a multiple bioactive ingredient formula (MBIF) comprising a mixture of natural substances has potential as an alternative intervention for individuals with ADHD. This systematic review aimed to assess the effectiveness and safety of MBIF in managing ADHD symptoms in children. Methods: A systematic search was conducted in MEDLINE (PubMed), Scopus, Web of Science (WOS), EMBASE, Google Scholar, JSTOR, and Cochrane databases to evaluate the efficacy of MBIF in treating children with ADHD. The extracted data included study title, author/authors, publication year, study design, target population, and findings. Results: Twelve studies met the inclusion criteria. The interventions included combinations of ADHD medications with supplements such as zinc (Zn), magnesium (Mg), and herbal extracts like Bacopa monnieri. Results varied, with some studies showing significant improvement in ADHD symptoms with the addition of bioactive ingredients, while others did not find significant differences. Conclusion: MBIFs may offer some benefit in managing ADHD symptoms, particularly when combined with standard medications. However, the effectiveness varies based on the type and combination of ingredients used. Further large-scale, high-quality RCTs are needed to confirm these…
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Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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