Hypomagnesaemia and role of magnesium supplementation during cardiopulmonary bypass in pediatrics cardiac surgery
Abstract
Background: A significant source of morbidity and mortality following cardiac surgery for congenital heart disease is postoperative arrhythmias. Patients with congenital cardiac disease are particularly susceptible to rhythm abnormalities in the early postoperative period. Little is known about the prevalence, danger signs, treatment, and prevention of early postoperative arrhythmias in juvenile cardiac surgery. An incidence of between 15% and 17.7% was observed in a recent report by Roos-Hesselink and Karamermer. Materials and Methods: This prospective study was conducted at Super speciality hospital GMC Nagpur, All patients with tetralogy of Fallot undergoing intra-cardiac repair in the Department of Cardiothoracic and Vascular Surgery between February 2019 to February 2020 were enrolled in this study. A total of 90 patients were included in this study.The patients receiving any antiarrhythmic medication either prior to surgery or intraoperative were excluded from the study.The patients were randomly assigned to one of the following groups: Group 1 (Mg0), receiving normal saline (placebo), group 2 (Mg25), receiving 25mg/kg of MgSO4, and group 3 (Mg50), and receiving 50mg/kg of MgSO4. Maximum total dose of MgSO4 did not exceed 2g. All subjects received a single bolus of either placebo or drug into the CPB circuit at the initiation of the rewarming period. MgSO4 (500mg/mL; 4mEq/mL). The composition of the bypass circuit and perfusion protocols were according to established…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 90 participants or records.
Read the paper
Related studies
- Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
- A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
- Bioaccessibility and bioavailability of phenolic compounds
- The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
- Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery
- Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.