Preliminary analysis of the role of magnesium in transplant-associated thrombotic microangiopathy via complement activation pathways
Abstract
Objective: This study aimed to retrospectively analyze the clinical features, potential risk factors, and prognosis of patients diagnosed with transplant-associated thrombotic microangiopathy (TA-TMA).Additionally, it explored the role of magnesium in the pathogenesis and prognosis of TA-TMA, particularly their impact on complement activation, to provide new insights into the prevention and treatment of TA-TMA.
Methods: A retrospective analysis was conducted on the clinical data of 619 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at Fujian Medical University Union Hospital, from August 2022 to August 2024.Among them, 14 patients diagnosed with transplant-associated thrombotic microangiopathy (TA-TMA) were included in the observation group (TA-TMA group). Meanwhile, a control group (non-TA-TMA group) was established by randomly selecting patients from the entire transplant cohort at a 1:3 ratio, ensuring a transplantation time difference within ±6 months. A TA-TMA mouse model was established by intraperitoneal injection of dimethyloxalyl glycine to induce TMA after transplantation. The experimental group received high-magnesium intervention, and complement activation marker sC5b-9 levels, platelet counts, lactate dehydrogenase (LDH) levels, and survival times were compared between the experimental and control groups to evaluate the effect of high-magnesium treatment on survival and prognosis.
Results: 1.The median age of the 14 TA-TMA…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 619 participants or records.
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