Abstract CT093: Bimodal relationship between magnesium supplementation and vitamin D status and metabolism: Results from a randomized trial
Abstract
Background: There is inconsistent evidence from epidemiologic studies and randomized trials on the role of vitamin D on colorectal adenoma recurrence, colorectal cancer incidence, and total cancer incidence. Previous in vitro and in vivo studies indicate vitamin D synthesizing and metabolizing enzymes are Mg-dependent. The 2015 Dietary Guidelines Advisory Committee determined that magnesium (Mg) is under consumed relative to the Estimated Average Requirement (EAR) in the US population. In a single study, patients with Mg-dependent vitamin-D-resistant rickets received intramuscular infusion with vitamin D up to 600,000 IU which did not lead to any improvements in vitamin D deficiency. However, supplementation with Mg substantially reverse the resistance to vitamin D treatment. We previously reported from observational studies that Mg intake significantly interacted with vitamin D in affecting vitamin D status and risk of mortality. In this first randomized trial examining the interaction between Mg and vitamin D, we tested our hypothesis that Mg supplementation alters vitamin D synthesis and metabolism depending upon baseline circulating 25(OH)D concentration. Methods: The Personalized Prevention of Colorectal Cancer Trial (PPCCT) is a double-blind 2×2 factorial randomized controlled trial which enrolled 250 participants and randomized them to placebo or a customized dose of Mg supplementation based on background dietary intakes levels. The current study is an…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 250 participants or records.
Read the paper
Related studies
- Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
- A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
- Bioaccessibility and bioavailability of phenolic compounds
- The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
- Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery
- Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.