Abstract 5894: Synergism between medium-chain fatty acid intake and global magnesium status on the risk of cancer mortality in the National Health and Nutrition Examination Survey (NHANES) 2005-2014
Abstract
Medium-chain fatty acids (MCFAs), a class of saturated fatty acids that exist naturally in dairy products and tropical oils, can regulate inflammation, insulin resistance, and immune response. Furthermore, in vitro and in vivo studies found MCFAs have strong anticarcinogenic properties. Recent evidence reveals MCFAs inhibits aerobic glycolysis in tumor cells. It is conceivable that MCFAs have an “anti-Warburg effect”. In a double-blind randomized trial (Personalized Prevention of Colorectal Cancer; NCT01105169), we found that 12-week personalized magnesium (Mg) supplementation led to significantly increased circulating levels of MCFAs, particularly caprylic acid (C8:0), which was due to enhanced microbial production. These novel findings suggest individuals with Mg sufficiency can receive supplies of MCFAs from microbiome whereas people with Mg deficiency cannot and so need MCFAs from intake. Thus, we hypothesized that the associations between intakes of C8:0 and risk of cancer mortality are modified by body Mg status. We tested this hypothesis in the NHANES, a nationally representative study. We recently developed the Mg depletion score (MDS) to assess Mg status and validated it against the invasive gold standard measure of Mg status. MDS performs better than either serum Mg or Mg intake at predicting Mg deficiency. We also found higher Mg intake was associated with reduced risks of inflammation and total mortality only among those with higher MDS scores, i.e., higher risk…
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