PP529 Topic: AS25–Sedation/Analgesia/Delirium/Withdrawal Syndrome/Other: RELATIONSHIP BETWEEN MELATONIN LEVELS IN BLOOD AND URINE WITH SLEEP QUALITY IN CHILDREN ADMITTED TO A PEDIATRIC ICU (PICU)
Abstract
Aims & Objectives: Melatonin is the hormone responsible for sleep and sleep-wake cycle regulation. The objective of this study has been to analyze the relationship between melatonin levels with sleep quality in critically ill children. Methods: Children admitted to Pediatric ICU (PICU) for more than 48 hours were included. Patient and sleep characteristics were collected over a 48 hour period. Furthermore, melatonin levels in blood and its metabolite in urine (6-SMEL) were collected in the early morning and late afternoon. Results: 40 children, with a median age 34.5 months and average of 7.5 days of admission at the time of the study, were studied. The longer the duration of the admission prior to the study, the lower the concentration of serum melatonin (p=0.04; r: -0.27) and 6-SMEL in urine at 7 am (p=0.001; r: -0.55). Higher levels of morning melatonin were correlated with higher number of nighttime awakenings (p=0.01; r: 0.35) and shorter time of continuous sleep (p=0.03; r: -0.29). High 6-SMEL morning levels were associated with shorter daily sleep (p=0.03; r: -0,34) and total sleep duration in 24 hours (p=0.01; r: -0.43). Higher 6-SMEL levels in the afternoon were correlated with higher number of nighttime awakenings (p=0.01; r: 0.46), shorter duration of continuous night sleep (p=0.03; r: -0.37) and shorter duration of total sleep in 24 hours (p=0.04; r: -0.38). Conclusions: Children admitted to PICU lose the circadian rhythm of melatonin secretion, showing high…
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