Brain Tumours Involving the Areas of the Circadian System Result in Disturbances in Melatonin Secretion, Fatigue and Poor Quality of Life
Abstract
Abstract Background: Sleep disturbances, circadian abnormalities and poor health are often reported in children with brain tumours. The objective of this study was to examine circadian function, sleep pattern, fatigue and mental health in these children. We hypothesized that children with tumours involving the areas of the circadian system have altered melatonin secretion. Design: Cross-sectional study. Methods: 309 children diagnosed with a tumour in the brain or cervical medulla and aged ≤18 years were identified, 174 met the inclusion criteria, and 68 consented to participate. They were divided according to their tumour location into 1) location involving the areas of the circadian system, i.e. diencephalon, pineal gland, brain stem and cervical medulla and 2) other areas. Sleep-wake patterns were assessed by two weeks of sleep diary recordings and actigraphy in 66 and 61 children, respectively. Diurnal saliva-melatonin levels were measured in 51 children. Sleep quality, fatigue and mental health were assessed in 65 children by Children’s Sleep Habits Questionnaire, Strengths and Difficulties Questionnaire and Pediatric Quality of Life Inventory, Multidimensional Fatigue Scale and Generic Core Scale. Results: All children had normal sleep-wake patterns without significant between-group differences. The children with tumours involving the areas of the circadian system had lower melatonin peak levels (p=0.03) and a tendency of lower levels at 00 h and 04 h (all p=0.06).…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 309 participants or records.
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