Studies on melatonin in children with sleep disorders
Abstract
Background: Melatonin is known to assist sleep-disturbance rhythms in children and it has been used empirically in sleep disorders clinics at the Mater Children’s Hospital, Brisbane, Australia, and elsewhere in the world. Presently, there is no conclusive data on melatonin usage with regard to standard evidence (systematic reviews), dose-response relationships and its impact on health-related quality of life. Despite its qualitative efficacy in assisting sleep disorders, melatonin is presently a complementary medicine and has not been subject to the stringent pre-marketing research and development required for registered pharmaceuticals for therapeutic usage in paediatric patient population. Therefore, the available data on evidence (efficacy/safety), dosing and health related quality of life is largely anecdotal. Inconclusive and variable published data in children adds to misconceptions about melatonin usage in sleep disorders. There is an urgent need to evaluate clinical, pharmacokinetic and evidence based approaches for studying melatonin in paediatric sleep disorders, with the overall goal of improving clinical outcomes in these patients. Aims:This thesis aimed to explore the evidence-based, analytical, clinical and behavioural studies on melatonin in children with sleep disorders with the hypothesis to evaluate if melatonin administration restores normal circadian rhythms and sleep propensity in children with mismatched circadian sleep patterns. Four areas were…
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