Evidence-Based Pathways to Healthy Aging: A Systematic Review and Meta-analysis of Lifestyle Interventions for Longevity and Well-Being
Abstract
Objective: To evaluate the impact of multidimensional lifestyle interventions on aging outcomes, including cognitive function, physical health, emotional well-being, and longevity.
Methods: This systematic review included 35 randomized controlled trials from 2014 through 2024 using MeSH terms such as "healthy aging," "nutrition," "physical activity," "mental health," "social connections," and "preventive healthcare." Inclusion was made based on whether studies have explored at least one lifestyle intervention among populations of 50 years and above with a reported outcome related to health and aging.
Results: 35 RCTs (n ≈ 25 000 participants) were included. Key findings were: Nutrition: The Mediterranean diet, antioxidant-rich foods, and protein intake were associated with cardiovascular benefits (RR = 0.78), reduced cognitive decline (OR = 0.72), and improved muscle mass (SMD = 0.45). Physical Exercise: Aerobic and resistance exercises enhanced cardiovascular fitness (MD in VO2 max = 3.6 mL/kg/min) as well as risk of frailty (RR = 0.67); Mental Health: Cognitive stimulation and mindfulness interventions reduced the risk of dementia (OR = 0.75) as well as stress levels (Standard Mean Difference -SMD = -0.65); Network Social: Friendship support interventions with community involvement attenuated the susceptibility to depression, by 30% (RR = 0.70), with improved life overall satisfaction (SMD = 0.55); Safe Harm Avoidance: Smoking treatment reduced cardiovascular outcome risks…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 25 participants or records.
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