Sleep and the Mediterranean diet: A systematic review and meta-analysis
Abstract
We conducted the current systematic review and meta-analysis to critically review and synthesize available evidence regarding the association between sleep duration, sleep quality, and chronotype with the Mediterranean diet (MedDiet) among the general population using observational studies. Online databases, including PubMed, Scopus, and ISI Web of Science, were searched from the earliest available date until December 2024. We enrolled 62 studies with a total sample size of 328,493. The mean age and BMI of the participants in the enrolled studies ranged from 6.1 to 74.7 years and 18.1-32.1 kg/m2. Individuals with sufficient sleep duration (OR: 1.39; 95 % CI, 1.04, 1.85; P = 0.030; I2 = 97.89 %, PQ-test 2 = 93.83 %, PQ-test 2 = 89.72 %, PQ-test < 0.001) had significantly increased odds of high MedDiet scores, compared to those with insufficient sleep duration, poor-quality sleep, and later chronotype, respectively. Our study revealed that sleep duration, sleep quality, and chronotype are lifestyle-related factors linked to MedDiet. However, more longitudinal studies and clinical trials are needed to investigate causality, mediating factors, and underlying mechanisms.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Tryptophan Metabolism and Gut-Brain Homeostasis
- Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review
- Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit
- Relationship between sleep disorders and gut dysbiosis: what affects what?
- The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research
- Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.