Participant Experiences from Chronic Administration of Sustained-Release GABA and Alpha-s1 Casein Hydrolysate compound Versus Melatonin on Sleep Quality: An Exploratory Analysis of a Single-Blind Clinical Trial
Abstract
Sleep difficulty is relatively common among people, and those affected often resort to short-term use of herbal supplements to ease the symptoms. Here we introduce and investigate the effects of a novel composite product, NatureU Sleep, that contains sustained-release gamma-aminobutyric acid (GABA) and alpha-s1 casein hydrolysate, on sleep quality compared to the commercially available drug-melatonin. The exploratory clinical trial was designed to assess the deep sleep conditions including 17 adult participants, with an expectation that 15 would complete the trial. Utilizing wearable monitoring devices, the study evaluates the impact of the test product on deep sleep duration and proportion. The results indicated a significant increase in deep sleep duration and proportion for participants consuming sustained-release GABA and alpha-s1 casein hydrolysate, suggesting its potential as an effective sleep aid without any observed adverse events. This study aimed to compare the acute effects of a single dose of NatureU Sleep versus a single dose of commercial melatonin on objective measures of deep sleep.
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 17 participants or records.
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