A review of neurophysiological relationships between sleep disorders and depression
Abstract
This review critically synthesizes current neurophysiological findings on the comorbidity between depression and sleep disorders. Drawing upon a multidisciplinary body of literature, the paper delineates overlapping neurochemical, hormonal, and inflammatory mechanisms. Further, it explores the role of astrocytic dysfunction and glutamate-GABA imbalance in reinforcing pathological feedback loops. By adopting an integrative framework, this review underscores the bidirectional and systemic nature of sleep disorder-depression comorbidity, offering insights into shared pathophysiological substrates and potential therapeutic targets for future research.
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