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The hidden clock: how chronotype is related to depression, anxiety, and stress in adolescents - insights from the EHDLA study

Miño C, Smith L, Cristi-Montero C, Gutiérrez-Espinoza H, Olivares-Arancibia J, Yañéz-Sepúlveda R, Stubbs B, López-Gil JF

International journal of mental health systems, 2025

703 participants · 4 citations

Abstract

Background: Depression, anxiety, and stress symptoms are common among adolescents; however, studies exploring their relationship with chronotype in European youth populations is scarce. This study aimed to evaluate the association between chronotype status and depression, anxiety, and stress symptoms in adolescents.

Methods: A secondary analysis of the Eating Healthy and Daily Life Activities (EHDLA) cross-sectional study was performed in 703 adolescents (56.3% girls) between 12 and 17 years from the Valle de Ricote, Spain. Chronotype preference was assessed using the Morningness/Eveningness Scale in Children (MESC), while symptoms were evaluated using the Depression, Anxiety, and Stress Scale (DASS-21). A robust generalized linear regression model was used to evaluate the associations between chronotype prefernces and symptoms of depression, anxiety and stress in adolescents.

Results: After adjusting for potential covariates (sex, age, socioeconomic status, body mass index, sleep duration, physical activity, sedentary behavior, and energy intake), the highest probability of having depression, anxiety, and stress was identified in those with an eveningness chronotype preference (depression: 27.4%, 95% confidence interval [CI] 17.5-40.1%; anxiety: 28.5%, 95% CI 18.6-41.0%; stress: 47.6%, 95% CI 34.1-61.5%). Conversely, the lowest probability was observed in adolescents with a morningness chronotype preference (depression: 11.9%, 95% CI 8.3-16.8%; anxiety: 15.4%, 95% CI…

How strong is the evidence?

Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 703 participants or records.

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