Common immunological pathways of anti-infection immunity and allergic reactivity modification in children associated with peculiarities of the modern educational process and environment quality
Abstract
This study is relevant due to humoral and cellular pathways of the immune response having much in common as well as its high sensitivity to factors of the modern educational process in school when building up anti-infection and anti-allergy protection. Our research objects were secondary schools with profound studies of some subjects (Type 1 schools) and ordinary secondary schools (Type 2 schools); overall, we examined 842 schoolchildren from Type 1 schools and 540 schoolchildren from Type 2 schools.
The aim of this study was to establish conditions and common pathogenetic sections of immunological pathways of anti-infection immunity and allergic reactivity modification associated with environmental exposures and exposure to factors of the modern educational process.
We analyzed how educational activities were organized in the analyzed schools; what food products were consumed by the participating schoolchildren daily and their chemical structure; basic aspects of schoolchildren’s lifestyles; quality of indoor air in classrooms; quality of ambient air in areas where the analyzed schools were located; prevalence of allergic diseases (ADs) and anti-infection immunity disorders; results of immunological tests and chemical blood tests; intensity of humoral anti-infection and post-vaccination immunity. The study involved odds ratio calculation, linear regression analysis, and neural network modeling.
As a result, we established that high educational loads, improper duration of…
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