The effect of cognitive-behavioral therapy on sleep disturbances and melatonin levels in a cohort of pregnant women
Abstract
The objective: to conduct a prospective analysis of the impact of cognitive behavioral therapy (CBT) and the level of endogenous melatonin in pregnant women with sleep disorders according to the Pittsburgh Sleep Quality Index (PSQI).Materials and methods. A randomized controlled trial was conducted in a group of 110 pregnant women with diagnosed sleep disorders. Sleep disorders were determined in the II and III trimesters of pregnancy using the PSQI questionnaire with additional questions for pregnant women.Study participants were randomly assigned to a main group (n=49) and a comparison group (n=61). To improve sleep in the main group 10 sessions of CBT were conducted over 10 weeks, and in the comparison group sleep hygiene psychoeducation was performed as generally recommended measures. In all study participant, the level of endogenous melatonin was determined indirectly by its metabolite – 6-sulfatoxymelatonin (6-SOM) in the urine.The condition of pregnant women in both groups was assessed for the effect of CBT at the beginning and after the end of treatment (week 10) using the PSQI questionnaire with additional questions for pregnant women and the level of 6-COM in urine. The impact of sleep disorders and CBT on the frequency of perinatal outcomes was also evaluated.Results. Pregnant women with sleep disorders had a reduced level of 6-SOM in urine. After the CBT sessions in the main group the PSQI indicators significantly decreased, and the level of 6-COM in the urine…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 110 participants or records.
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