Clinical phenotypes of bronchial asthma in children with insufficient control: associations with sleep disorders and quality of life
Abstract
In childhood, sleep disturbances for a certain period of time are accompanied by depressive or irritable mood, loss of concentration, learning ability and contribute to memory impairment, and the final result of poor sleep is an increased risk of obesity, diabetes, heart diseases.
Objective - to carry out a comparative analysis of the life quality in individual phenotypes of bronchial asthma, taking into account the disease control on the base of self-assessment by children and their parents using the PAQLQ and PACQLQ questionnaires.
Material and methods. Using a random sampling method under conditions of the RMNE (Regional Municipal Nonprofit Enterprise) "Chernivtsi Regional Clinical Children's Hospital", 131 children with persistent bronchial asthma were examined to establish the nature of the inflammatory phenotype of the bronchial tree by means of studying the absolute content of eosinophil granulocytes in peripheral blood and the percentage of acidophilic leukocytes in sputum. Depending on the results obtained, the children were divided into two clinical groups of comparison. The first (I) clinical group was formed by 65 children, in whom the average relative content of eosinophils in sputum exceeded 3% and constituted 16.2 ± 2.28%. Given phenotype of the disease was defined as eosinophilic. The second (II) group (non-eosinophil phenotype) included 66 sick schoolchildren, in whom the average content of eosinophilic granulocytes in sputum was only 0.6 ± 0.1% (p < 0.001)…
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