0633 Hypoglossal Nerve Stimulation for the Treatment of Obstructive Sleep Apnea in 4 Adolescents with Trisomy 21
Abstract
OSA is one of the most common comorbidities seen in pediatric patients with Trisomy 21 (T21) with a prevalence of up to 79% compared to 1-5% seen in the general pediatrics population. Uncontrolled OSA can have serious clinical consequences, including cognitive and behavioral impairment and cardio-respiratory sequelae such as pulmonary hypertension, making OSA particularly important to treat. Unfortunately, OSA can be difficult to manage in patients with T21 due to a multitude of anatomic risk factors and difficulties with adherence to standard therapy (i.e. positive airway pressure). However, hypoglossal nerve stimulation (HNS) has recently emerged as a promising therapy for adolescents with T21. In this study, we aimed to evaluate the safety and efficacy of HNS in adolescents at Oklahoma Children’s Hospital.
In a retrospective chart review, we evaluated the tolerance, subjective changes, and apnea-hypopnea index (AHI) differences before and after implantation of HNS in adolescents with T21. Baseline data included demographics, patient/parental experience, and polysomnography (PSG) results. Only adolescents (ages 13-19) with T21 were included. The primary outcome measurement was AHI following HNS implantation compared to AHI prior to HNS implantation. Secondary outcomes included tolerance to the HNS device and subjective differences in symptoms after implantation.
We evaluated 4 adolescents who received HNS implantation. Each patient had improvement in AHI with absolute…
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