Sleep Quality and Depressive Symptoms in Clinically Stable Pediatric Familial Mediterranean Fever: Associations with Disease Severity and Developmental Factors
Abstract
Highlights What are the main findings? Clinically stable children and adolescents with FMF did not exhibit poorer sleep quality or greater depressive symptom severity than age- and sex-comparable healthy controls. Increasing age, particularly adolescence, was independently associated with poor sleep quality, whereas disease severity assessed using the International Severity Scoring System for Familial Mediterranean Fever (ISSF) was not. What are the implications of the main findings? Developmental factors may contribute more strongly to sleep quality than clinically assessed disease severity in children and adolescents with FMF. Routine assessment of sleep quality and emotional well-being, particularly during adolescence, should be considered as part of comprehensive multidisciplinary care for pediatric FMF. Abstract Background: Familial Mediterranean Fever (FMF) is a chronic autoinflammatory disease that may adversely affect sleep quality, emotional well-being, and other patient-reported outcomes during childhood and adolescence. However, previous pediatric studies have frequently included heterogeneous patient populations with varying disease activity, limiting understanding of the relationship between disease severity and psychosocial functioning. Objective: To evaluate sleep quality and depressive symptoms in clinically stable children and adolescents with FMF during attack-free periods and to investigate their relationships with disease severity assessed using the…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 72 participants or records.
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