The effect of neurotransmitters on the course of functional gastrointestinal disorders associated with emotional volitional disturbances caused by stress in children
Abstract
Background. The medico-social significance of functional gastrointestinal disorders (FGID) in children is due to their prevalence and impact on the quality of life of patients. According to the biopsychosocial model, FGID are heterogeneous diseases that arise as a result of a complex interaction of biological, psychoemotional, and psychosocial factors. Objective: based on the generalization of available literature data, to highlight the influence of serotonin and melatonin neurotransmitters on the course of FGIR associated with emotional volitional disturbances caused by stress in children. Materials and methods. Modern domestic and international scientific literature on the influence of serotonin and melatonin on the course of FGIR associated with emotional volitional disturbances caused by stress in children was reviewed and analyzed. To search for literary sources, the Scopus, PubMed, ResearchGate, Wiley Online Library, and Google Scholar databases were studied for 2016–2024, a total of 98 sources. Results. Modern etiopathogenetic factors for the occurrence of FGIR in children are described, with the key components of their biopsychosocial model highlighted. The influence of stressors on the development of mental disorders in children with FGIR, in particular emotional and volitional changes, is considered. We have demonstrated the role of serotonin and melatonin in the regulation of mood, emotions, sleep, behavior, anxiety, depression, etc. The importance of these…
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