Molecular and Clinical Perspectives on the Regulation of Sleep and Uric Acid Metabolism
Abstract
Uric acid, the end product of purine metabolism, is closely associated with metabolic disorders, including gout and metabolic syndrome. Emerging evidence highlights a bidirectional relationship between uric acid metabolism and sleep regulation. Elevated uric acid levels can adversely affect sleep quality via oxidative stress and neuroinflammatory pathways, while sleep deprivation may promote uric acid synthesis and impair its excretion. This reciprocal interaction may form a vicious cycle, potentially accelerating the onset and progression of various metabolic diseases. This review summarizes recent clinical and experimental findings, focusing on the molecular mechanisms underlying the bidirectional regulation between uric acid metabolism and sleep. The implications of this relationship in the pathophysiology of metabolic disorders are discussed. Understanding this interplay underscores the importance of targeting uric acid levels and sleep quality as integrated strategies for managing metabolic diseases. These insights provide a foundation for the development of novel therapeutic interventions designed to enhance clinical outcomes in metabolic syndrome.
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