0037 Investigating Common Genetic Factors Between Obstructive Sleep Apnea and Prostate Cancer
Abstract
Abstract Introduction Cancer is one of the leading causes of death in the world. Studies have highlighted the possible association between obstructive sleep apnea (OSA) and an increased risk of incidence or prevalence of some types of cancer, especially prostate cancer. However, the extent to which genes that are related to both conditions contribute to their comorbidity is still unclear. The aim of this study was to evaluate the intersection of risk genes found in both OSA and prostate cancer. Methods Two sets of genes associated respectively with OSA and prostate cancer were manually curated and then compared to obtain an intersection gene list. Fisher’s exact test was employed to evaluate the statistical significance of the overlap, with a significance threshold of p-value< 0.05. The identification of enriched pathways among the intersection gene list was performed using the Benjamini–Hochberg test, with a significance threshold of adjusted p-value< 0.05. A functional network was generated from the intersect gene list which was used as an input in a protein–protein interaction analysis conducted using the String database. Results Sixty-eight genes overlapped between prostate cancer risk genes and OSA-associated genes, indicating more overlap than expected by chance (odds ratio=2.665; p=2.606E–10). This intersect list was associated mainly with hypoxia, apoptosis, oxidative stress, and cell cycle, proliferation, or cell damage. The hypoxia-inducible factor (HIF)-1…
Read the paper
Related studies
- Tryptophan Metabolism and Gut-Brain Homeostasis
- Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review
- Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit
- Relationship between sleep disorders and gut dysbiosis: what affects what?
- The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research
- Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.