0038 Kinesin Binding as a Shared Pathway Underlying the Genetic Basis of Male Infertility and Insomnia
Abstract
Abstract Introduction Fertility problems are becoming increasingly common, with issues relating to men accounting for half of the cases. In addition to all the known causes of male infertility, some complaints are of idiopathic origin, and lifestyle, including sleep habits, might be an important underlying factor. Sleep disorders such as insomnia, which are prevalent in the population, might interfere in male fertility. Therefore, we aimed to perform an in silico study to test whether male infertility and insomnia share genetic risk variants, and to identify any molecular, cellular, and biological interactions between them. Methods Two lists of gene sets were manually curated through a literature review using PUBMED, 1 associated with male infertility (454 genes) and the other with insomnia (921 genes). The statistical significance of the gene list overlap was performed by the Fisher Exact test using Nematode Bioinformatics and Molbiotools online tools. This analysis considered a total of 21,196 genes in the human genome with a statistical threshold of P-value< 0.05. The enriched terms over-represented in the intersect gene list were acquired from the Benjamini-Hochberg and the protein-protein interaction (PPI) analysis was performed via String database. Results Among these genes, 28 were common for both lists, representing more overlap than expected by chance (Fisher's exact test, p-value=0.041). The biological function of the genes contained in the intersection gene list…
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