Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?
Abstract
Background: The traditional healthcare model, focused on symptom management, has shown limitations in addressing chronic diseases. In response, Bioregulatory Systems Medicine (BrSM) has emerged, an approach that promotes the body's self-regulation through multi-component drug and phytotherapeutic treatments. Its potential application in dentistry, particularly in periodontitis, has spurred the study of various natural molecules with the potential to prevent or reduce bone resorption. This qualitative systematic review analyzes the available evidence from animal and human models in the field of bioregulatory periodontal medicine.
Methods: A qualitative systematic review was conducted according to PRISMA-P guidelines. Animal and human studies published in English or Spanish within the last 10 years were included. The search was performed in five databases (SciELO, CENTRAL, PubMed, LILACS, and Web of Science) using MeSH terms. Data selection and analysis were performed in duplicate. Tools were applied to assess the risk of bias: SYRCLE for animal studies, Newcastle-Ottawa for observational studies, and RoB 2 for randomized controlled trials.
Results: A total of 1,252 articles on calendula, caffeine, piperine, curcumin, and omega-3 fatty acids were found. Fifty-three studies were selected based on inclusion and exclusion criteria. Calendula and piperine reduced bone loss and inflammation in animal models. Curcumin and omega-3 fatty acids showed these effects in both animals and…
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Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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