The Lipid Raft Hypothesis: The Relation among Omega-3 Fatty Acids, Depression and Cardiovascular Diseases
Abstract
Background: Depression and cardiovascular diseases (CVDs) exist frequently as comorbid conditions, suggesting their common etiologies. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) play important roles in inflammation and brain functions, and they appear to be a possible interface between depression and CVDs. Methods: We reviewed all recently published papers on n-3 PUFAs and lipid rafts to look for their implications in causing CVDs and depression. Results: In the literature, we found that lipid raft formations and disruptions are critically important in regulating of neurotransmission signaling and receptor functions, which in turn might be involved in causing depression and CVDs. In addition to neurotransmission, n-3 PUFAs have shown to possibly regulate immunity and neuroendocrine function via lipid raft modulations. Conclusion: This review has provided evidences for the role of n-3 PUFAs in causing depression and CVD. We also propose a new hypothesis about cellular mechanisms mediated by lipid rafts.
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