The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial Function Pilot
Abstract
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue. There are no current targeted therapies to prevent or reverse the chronic inflammation of obesity, and a better understanding of these inflammatory pathways in humans is key to future therapeutic interventions. This project will determine both the anti-inflammatory potential of the SGLT2 inhibitor empagliflozin, and the contribution of adipose inflammation to surrogate measures of cardiovascular disease in a randomized controlled trial of obese patients.
Conditions: Obesity, Pre-diabetes.
Primary outcome: Change in Adipose Pro-inflammatory T Helper Type 1 Cell Percentages After 3 Months; Change in Flow-mediated Dilation After 3 Months; Change in Liver Steatosis at 3 Months.
Enrollment: 29 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 29 participants or records.
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