Augmentation of antidepressants with unsaturated fatty acids omega-3 in drug-resistant depression
Abstract
AIM: The aim of this paper was to evaluate the impact of augmenting administered antidepressant treatment of patients suffering from a severe episode of treatment-resistant recurrent depression or bipolar affective disorder with omega-3 fatty acids and comparing the obtained results with those achieved in the groups of patients potentiated with lithium or lamotrigine. METHODS: The research subjects were 21 patients diagnosed with a severe episode of treatment-resistant recurring depression in the course of recurrent depression disorders- or bipolar affective disorders. Patient eligibility included failure to respond to at least two 4-week antidepressant treatments (venlafaxine at a dose of up to 300 mg/day or paroxetine at up to 60 mg/day). The regular antidepressant treatment regimen was augmented by the "eye-q" preparation with a course of 24 capsules per day (2.2 g of EPA, 700 mg of DHA, 240 mg of GLA, 40 mg of vitamin E, primrose oil). The patients received the preparation for at least 4 weeks. The comparison groups consisted of the patients suffering from the current episode of severe treatment-resistant depression, treated by potentiating antidepressant treatment with lithium and lamotrigine. RESULTS: The initial intensity of depression symptoms on the HDRS scale was 30 +/- 6, following a 4-week potentiation HDRS score was 11 +/- 10. Taking into account a significantly higher initial intensity of depression, clinical improvement upon administering fatty acids was…
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