Efficacy of esketamine on perioperative anxiety in patients receiving anesthesia: a systematic review and meta-analysis of RCTs
Abstract
Objective: This study aimed to assess the impact of esketamine on perioperative anxiety, including its frequency, intensity, and score variations, across different surgical procedures by analyzing data from randomized controlled trials (RCTs).
Methods: A comprehensive literature search was performed across PubMed, Embase, the Cochrane Library, and Web of Science to identify relevant RCTs evaluating esketamine. Statistical analyses were conducted using Review Manager version 5.4 and Stata. Studies were included if they were RCTs involving anesthetized adult patients comparing esketamine with others, reporting of perioperative outcomes and sufficient data for meta-analysis. Studies were excluded for being reviews/editorials/case reports, conference abstracts, pediatric-focused, unpublished, or non-English. Primary outcomes contained change in anxiety/depression score and anxiety/depression Score. Secondary outcomes contained change in sleep/pain score and perioperation data. To assess publication bias, funnel plot visualization and Egger's test were employed.
Results: A total of eight RCTs involving 1,101 participants fulfilled the inclusion criteria. The pooled analysis indicated that esketamine administration led to a significant reduction in perioperative anxiety levels compared to control interventions (SMD = -0.36; 95% CI: -0.67 to -0.06; p < 0.0001; I² = 84%). However, no statistically significant improvements were observed in sleep parameters, pain relief, surgical or…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,101 participants or records.
Read the paper
Related studies
- Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review
- Effects of omega-3 polyunsaturated fatty acid intake in patients with chronic kidney disease: Systematic review and meta-analysis of randomized controlled trials
- Effect of omega-3 fatty acids on cognition: an updated systematic review of randomized clinical trials
- The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: A narrative review
- Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review
- Omega-3 fatty acid nanocarriers: Characterization and potential applications
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.