Non-pharmacological interventions for antipsychotic drug-related metabolic abnormalities: a systematic narrative review
Abstract
BACKGROUND: Antipsychotic treatment is commonly associated with weight gain, disturbances in glucose and lipid metabolism, and an increased risk of cardiovascular disease, representing a major clinical challenge in long-term psychiatric care. In recent years, randomised controlled trials have evaluated a range of non-pharmacological interventions targeting antipsychotic drug-related metabolic outcomes. However, substantial variability exists across studies in terms of intervention components, outcome measures, and reported effects, resulting in marked heterogeneity of the available evidence. A systematic synthesis of evidence derived from randomised controlled trials is therefore warranted. METHODS: This review was conducted in accordance with the PRISMA 2020 guidelines. Multiple English-language databases were systematically searched to identify randomised controlled trials conducted in populations receiving antipsychotic treatment that examined the relationship between non-pharmacological interventions and metabolic-related outcomes. Study selection was performed based on predefined inclusion and exclusion criteria. Data were extracted on study characteristics, intervention components, intervention duration, and primary metabolic outcomes. Methodological quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool for randomised controlled trials. RESULTS: A total of 42 randomised controlled trial publications were included.…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 18 participants or records.
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