Association of seafood consumption with sleep quality according to high sensitivity C-reactive protein levels in Korean adults
Abstract
Objective: The consumption of seafood, which is major sources of n-3 polyunsaturated fatty acids, such as docosahexaenoic and eicosapentaenoic acids, has been associated with sleep quality. Seafood and its bioactive components may enhance sleep quality by regulating systemic inflammation and neuroendocrine pathways. However, longitudinal studies examining the interplay between seafood consumption, sleep quality, and inflammatory status are lacking. Therefore, in this cohort study of 2332 participants from the Korean Genome and Epidemiology Study, we investigated the potential modulatory role of inflammatory status for the association between seafood consumption and the risk of poor sleep quality.
Methods and measurements: Dietary intake was assessed using a validated 106-item food frequency questionnaire. High-sensitivity C-reactive protein (hs-CRP) levels were assessed as a marker of systematic inflammatory status. Sleep quality was assessed using Pittsburgh Sleep Quality Index. The hazard ratio (HR) and 95% confidence interval (CI) for the risk of poor sleep quality was estimated using Cox proportional hazards model.
Results: After 6 years of follow-up, 118 and 192 cases of poor sleep quality were documented among men and women, respectively. The greater seafood consumption was significantly associated with lower risk of poor sleep quality. The multivariable-adjusted HR (95% CI) comparing the highest with the lowest tertile of seafood consumption was 0.66 (0.45-0.98)…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 2,332 participants or records.
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