Rapid Rescue From Hyperammonemic Coma After Valproic Acid Poisoning: Dual Therapy With Continuous Renal Replacement Therapy and L-Carnitine Supplementation
Abstract
Valproic acid is a commonly prescribed drug used in various conditions including seizures, bipolar disorder, mood disorder, and migraine headaches. Confusion and lethargy among patients on valproic acid need urgent attention as it can cause increased levels of ammonia, which can lead to the development of cerebral edema and even cerebral herniation in severe cases. Here, we describe a case of hyperammonemic coma induced by valproic acid toxicity. The condition was rapidly resolved using dual therapy involving extracorporeal removal and levocarnitine.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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