Evidence Hub

Psychological-dietary interactions in chronic disease management: mechanisms and integrated intervention strategies

Liu X, Leng H, Li Z, Deng X, Tian B, Xiao X, Sun Y

Frontiers in nutrition, 2026

Abstract

Objective: This narrative review aims to summarize evidence from nutritional psychiatry, behavioral medicine, and chronic disease management, examine the relationship between psychological factors and dietary behaviors in chronic disease management, and discuss potential mechanisms, disease-specific manifestations, and clinical management approaches.

Background: Chronic disease management involves not only the control of disease-related indicators but also the long-term maintenance of dietary behaviors, treatment adherence, and self-management. Stress, anxiety, depression, reduced self-efficacy, and disease-related distress may affect food choices, eating behaviors, and dietary adherence, while dietary patterns, nutrient intake, and dietary restriction may also be associated with emotional and cognitive status. Therefore, psychological factors and dietary behaviors may influence each other during long-term chronic disease management.

Results: Existing evidence suggests that psychological factors and dietary behaviors may be bidirectionally associated. Psychological distress may be related to emotional eating, preference for energy-dense foods, excessive dietary restriction, and reduced dietary adherence, while dietary behaviors may also be associated with psychological status and chronic disease management through pathways involving the hypothalamic-pituitary-adrenal (HPA) axis, reward processing, inflammation, the gut-brain axis, and metabolic changes. These relationships…

Read the paper

Related studies

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free