Effect of Oral Lyophilized Cornelian Cherry (Cornus Mas L.) Fruit on Selected Cardiometabolic, Vascular, Gut, Ocular and Bone Metabolism Parameters in Patients With Metabolic Syndrome
Abstract
This randomized, double-blind, placebo-controlled, parallel-group study evaluated the effects of six-month oral supplementation with Cornus mas fruit lyophilizate in patients with metabolic syndrome. Participants were assigned to receive either 8 g of Cornus mas fruit lyophilizate once daily or a matching placebo. Ophthalmic assessments included best-corrected visual acuity, slit-lamp examination, dilated fundus examination, applanation tonometry, and Doppler ultrasonography of the ophthalmic, central retinal, and posterior ciliary arteries. Cardiometabolic and biochemical parameters were also assessed at baseline and after 3 and 6 months of supplementation.
Conditions: Metabolic Syndrome.
Primary outcome: Red Blood Cell Count; CRP; lipid profile; urea level test; creatinine test; insulin test; The OGTT (Oral Glucose Tolerance Test); A fibrinogen test; An SHBG (sex hormone-binding globulin) test; cortisol test; The 25(OH)D3 test; A parathyroid hormone (PTH); plasma renin activity; An aldosterone test; Adipokine tests; An FMD (Flow-Mediated Dilation) ultrasound scan; ABPM (Ambulatory Blood Pressure Monitoring); Bioimpedance analysis (BIA); Densitometry; A urine test; a stool test; the visual field test; A visual acuity test; An intraocular pressure test; Periorbital blood flow assessment; biomicroscopy; funduscopy; White Blood Cell Count; Platelet Count; Hemoglobin Concentration; Hematocrit; Mean Corpuscular Volume; Neutrophil Count; Lymphocyte Count.
Enrollment: 55…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 55 participants or records.
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