Fracture risk, bone density and vitamin D in diabetic women
Abstract
BACKGROUND. Aging is associated with the increasingprevalence of both type 2 diabetes mellitusand osteoporosis, especially in the elderly and femalepopulation.SUBJECTS AND METHODS. We conducted a studyto evaluate the correlation between vitamin D deficiency,type 2 diabetes (DMT2), and osteoporosis in agroup of Italian women aged 40 to 75 years, comparingbiochemical-clinical parameters, anthropometricparameters, and results of instrumental investigations,such as the MOC-DEXA examination.RESULTS. The results show a lower bone mineraldensity and, consequently, an increased risk of osteoporosisfractures in patients with type 2 diabetes (DMT2).The responsible mechanism is particularly complexand not yet fully clarified. In addition, there is a negativecorrelation between plasma levels of vitamin D(25(OH)D) and an increase in insulin resistance withan increase in blood glycated hemoglobin (HbA1c); inother words, there is a higher mean vitamin D value innon-diabetic patients than in the population of womenwith diabetes.CONCLUSIONS. Vitamin D deficiency plays a keyrole in the development of insulin resistance as wellas in the development of osteoporosis and, in patientswith type 2 diabetes mellitus, there is a greater loss ofbone matrix integrity and consequently there is a significantincrease in the risk of bone fracture. This figureis significant for future preventive and therapeuticclinical choices.
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