Bacterial profile, antimicrobial susceptibility, and associated factors of urinary tract infection among people living with HIV at Debre Markos Comprehensive Specialized Hospital, Ethiopia
Abstract
Urinary tract infection (UTI) is a common bacterial infection among people living with HIV (PLWHIV) and can cause complications, particularly due to antimicrobial resistance. Data on UTIs among PLWHIV in Ethiopia are limited. This study assessed the bacterial profile, antimicrobial susceptibility, and associated factors of UTIs among 255 PLWHIV attending the ART outpatient clinic at Debre Markos Comprehensive Specialized Hospital from March to June 2025. Clean-catch midstream urine samples were inoculated on MacConkey and blood agar to identify pathogens, and antimicrobial susceptibility tested by Kirby-Bauer disk diffusion method. Statistical significance was set at p ≤ 0.05 with 95% confidence intervals. UTIs were identified in 28 participants (11%), with E. coli (46.4%), S. aureus (21.4%), and P. aeruginosa (14.3%) predominating. Female sex (AOR = 2.48; 95% CI 1.45-6.27; p = 0.010), HIV RNA > 1000 copies/mL (AOR = 6.30; 95% CI 4.52-14.61; p = 0.001), CD4 + 3 (AOR = 3.17; 95% CI 1.14-9.52; p = 0.028), and being symptomatic (AOR = 3.80; 95% CI 1.63-8.74; p = 0.024) were significantly associated with UTIs. The multidrug-resistant prevalence was 17.9%, highlighting the need for strengthened diagnostics, susceptibility-guided therapy, routine screening, and PLWHIV education on perineal hygiene to improve management and limit antimicrobial resistance.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.