Burden of Multidrug-Resistant Uropathogens and Their Antimicrobial Susceptibility Among Hospitalized Patients: A Single-Center Retrospective Analysis
Abstract
Background Urinary tract infections (UTIs) represent a major global health challenge, with the rise of multidrug-resistant (MDR) uropathogens significantly complicating empiric treatment and increasing medical costs. The objective of this study was to determine the local burden of MDR UTIs and the patient characteristics associated with it, characterize the causative pathogens, and describe their antimicrobial susceptibility patterns in a community hospital setting. Methods A retrospective cross-sectional study was conducted at Phelps Hospital in Sleepy Hollow, NY, USA, utilizing 392 urine samples collected from inpatients between February and May 2026. MDR status was defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories. Bacterial isolates were identified using automated methods, followed by antimicrobial susceptibility testing interpreted according to Clinical and Laboratory Standards Institute (CLSI) 2022 guidelines. Results Among 286 symptomatic patients, 70 (70/286; 24.47%) had MDR UTIs. Escherichia coli was the predominant pathogen (48/70 samples; 68.6%), of which 47.91% (23/48 samples that grew Escherichia coli) were extended-spectrum beta-lactamase (ESBL)-producing. A significant finding was that among the MDR isolates that grew Enterococcus, all were vancomycin-resistant. The most common clinical characteristics associated with MDR infection were prior antibiotic use within six months (42/70; 60%) and hospitalization…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 286 participants or records.
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