Effect of alkalinisation of urine on the efficacy of levofloxacin in urinary tract infection
Abstract
BACKGROUNDIn urinary tract infection, levofloxacin is used to treat both complicated and uncomplicated cases.To reduce the pain and burning sensation in lower UTI, physicians commonly prescribe an alkaliniser like disodium hydrogen citrate along with levofloxacin.The combined effect of these two drugs is unknown.Aim of our study was to find out the effect of alkalinisation of urine on the efficacy of levofloxacin in uncomplicated urinary tract infection.Study Design-The study was conducted at general screening outpatient department of R. G. Kar Medical College and Hospital.The study was a randomised assessor-blind study. MATERIALS AND METHODSPatients with symptoms of lower UTI were randomised and divided into two groups A and B. Group A were prescribed levofloxacin 250 mg once daily for 3 days and group B were prescribed levofloxacin 250 mg once daily for three days along with disodium hydrogen citrate 10 mL thrice daily for 3 days.Before prescribing the drugs, urine sample was sent for routine and culture sensitivity test.Statistical Analysis Used-We applied Pearson's method. RESULTSIn our study, it is found that levofloxacin 250 mg daily for 3 days can eradicate the urinary pathogens in 93% of cases, but when levofloxacin is combined with disodium hydrogen citrate, it can eradicate only 70% of uropathogens in uncomplicated cases of lower UTI.The possible explanation of this reduced action of levofloxacin is that alkali solution may prevent the absorption of levofloxacin…
How strong is the evidence?
Evidence Hub reads this as a randomized trial. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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